Germs, Hosts, and the Origin of Frank Macfarlane Burnet's Concept of "Self " and "Tolerance," 1936-1949

  title={Germs, Hosts, and the Origin of Frank Macfarlane Burnet's Concept of "Self " and "Tolerance," 1936-1949},
  author={Hyung Wook Park},
  journal={Journal of the History of Medicine and Allied Sciences},
  pages={492 - 534}
  • H. Park
  • Published 14 September 2006
  • Biology
  • Journal of the History of Medicine and Allied Sciences
In the early twentieth century, the living organism's ability to distinguish its "self" from foreign entities such as bacteria, viruses, transplanted tissue, or transfused blood was a major problem in medical science. This article discusses how the Australian immunologist Frank Macfarlane Burnet arrived at a satisfactory explanation of this problem through his 1949 theory of "self" and "tolerance." Burnet's theoretical work began from his study of diverse factors affecting the conditions of the… 
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