Germs, Hosts, and the Origin of Frank Macfarlane Burnet's Concept of "Self " and "Tolerance," 1936-1949

@article{Park2006GermsHA,
  title={Germs, Hosts, and the Origin of Frank Macfarlane Burnet's Concept of "Self " and "Tolerance," 1936-1949},
  author={Hyung Wook Park},
  journal={Journal of the History of Medicine and Allied Sciences},
  year={2006},
  volume={61},
  pages={492 - 534}
}
  • H. Park
  • Published 14 September 2006
  • Medicine
  • Journal of the History of Medicine and Allied Sciences
In the early twentieth century, the living organism's ability to distinguish its "self" from foreign entities such as bacteria, viruses, transplanted tissue, or transfused blood was a major problem in medical science. This article discusses how the Australian immunologist Frank Macfarlane Burnet arrived at a satisfactory explanation of this problem through his 1949 theory of "self" and "tolerance." Burnet's theoretical work began from his study of diverse factors affecting the conditions of the… 
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References

SHOWING 1-10 OF 108 REFERENCES
The ‘Cytogenetics’ of Black and White Guinea Pig Skin
TLDR
Analysis of the type undertaken is only made possible by the circumstance that black skin is capable of 'infecting' white, and endowing it with its own cellular phenotype ; a process which has the same methodological significance for the study of cellular heredity as the phenomenon of segregation has for Mendelian genetics.
The ‘Burnet Era’ of immunology: Origins and influence
  • I. Mackay
  • Biology, Medicine
    Immunology and cell biology
  • 1991
TLDR
The Burnet era would be a memorable late afternoon in 1957 since it was then that Burnet first published the clonal selection theory of acquired immunity and no other concept has had a greater influence on contemporary immunology.
‘Actively Acquired Tolerance’ of Foreign Cells
The experiments to be described in this article provide a solution—at present only a ‘laboratory’ solution—of the problem of how to make tissue homografts immunologically acceptable to hosts which
The role of the virus in origin-of-life theorizing
  • S. Podolsky
  • Biology, Medicine
    Journal of the history of biology
  • 1996
TLDR
Of perhaps still more fundamental importance in attacking the problem of the origin of life is the definition of "life" itself; and here scientists must bring their entire worldviews - derived from their individual research, professional affiliations, metaphysical speculations, and personal associations - to focus upon this elusive concept.
Selfhood, Immunity, and the Biological Imagination: The Thought of Frank Macfarlane Burnet
The language of self and nonself has had a prominent place inimmunology. This paper examines Frank Macfarlane Burnet's introductionof the language of selfhood into the science. The distinction
CHANGES OF TWENTY‐FIVE YEARS IN THE OUTLOOK ON INFECTIOUS DISEASE
TLDR
The last quarter century has seen, first, immense technical applications of bacteriological knowledge to the medical problems of the Great War of 1914 to 1918, second, the growth of knowledge about the filterable viruses, almost to the status of an independent science, and finally the gradual development of what is best termed an ecological point of view in regard to the general problems of infectious disease.
‘Trouble from within’: allergy, autoimmunity, and pathology in the first half of the twentieth century
TLDR
It is claimed that the emergence of the notion of autoimmunity in the 1950s must be considered as part of a long develolpment in thought about pathology throughout the twentieth century, namely the conceptualisaiton of disease as a reactive and self-destructive process.
Genetics and immunology
TLDR
The object is primarily to describe the immunological techniques which have been applied to genetic investigations and to discuss the significance of immunological findings.
EPIDEMIOLOGY OF LYMPHOCYTIC CHORIOMENINGITIS IN A MOUSE STOCK OBSERVED FOR FOUR YEARS
  • E. Traub
  • Biology, Medicine
    The Journal of experimental medicine
  • 1939
TLDR
Evidence is presented which suggests that the shift in the severity of the disease was caused by a decrease of the pathogenicity of the virus for embryonic mouse tissue and a concurrent increase of the resistance to intrauterine infection of the mice from the infected stock.
The Collected Papers of Paul Ehrlich
  • J. Fruton
  • Computer Science
    The Yale Journal of Biology and Medicine
  • 1957
TLDR
Although his studies on immune reactions and on chemotherapy came after 1890, the earlier work was no less important, since it included his research on the use of aniline dyes for hematological and bacteriological staining, for the study of biochemical reactions, and for the examination of pathological tissues and fluids.
...
1
2
3
4
5
...