Germline variation in complement genes and event-free survival in follicular and diffuse large B-cell lymphoma.

@article{Charbonneau2012GermlineVI,
  title={Germline variation in complement genes and event-free survival in follicular and diffuse large B-cell lymphoma.},
  author={Bridget Charbonneau and Matthew J Maurer and Zachary S. Fredericksen and Clive S Zent and Brian K Link and Anne J. Novak and Stephen M Ansell and George J. Weiner and Alice H. Wang and Thomas E Witzig and A. Latif Dogan and Susan L. Slager and Thomas Matthew Habermann and James R. Cerhan},
  journal={American journal of hematology},
  year={2012},
  volume={87 9},
  pages={880-5}
}
The complement pathway plays a central role in innate immunity, and also functions as a regulator of the overall immune response. We evaluated whether polymorphisms in complement genes are associated with event-free survival (EFS) in follicular lymphoma (FL) and diffuse large B-cell (DLBCL) lymphoma. We genotyped 167 single nucleotide polymorphisms (SNPs) from 30 complement pathway genes in a prospective cohort study of newly diagnosed FL (N = 107) and DLBCL (N = 82) patients enrolled at the… CONTINUE READING