Germline stem cells and follicular renewal in the postnatal mammalian ovary

@article{Johnson2004GermlineSC,
  title={Germline stem cells and follicular renewal in the postnatal mammalian ovary},
  author={J. Johnson and Jacqueline Canning and T. Kaneko and J. Pru and J. Tilly},
  journal={Nature},
  year={2004},
  volume={428},
  pages={145-150}
}
  • J. Johnson, Jacqueline Canning, +2 authors J. Tilly
  • Published 2004
  • Biology, Medicine
  • Nature
  • A basic doctrine of reproductive biology is that most mammalian females lose the capacity for germ-cell renewal during fetal life, such that a fixed reserve of germ cells (oocytes) enclosed within follicles is endowed at birth. Here we show that juvenile and adult mouse ovaries possess mitotically active germ cells that, based on rates of oocyte degeneration (atresia) and clearance, are needed to continuously replenish the follicle pool. Consistent with this, treatment of prepubertal female… CONTINUE READING

    Figures and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Paper Mentions

    INTERVENTIONAL CLINICAL TRIAL
    Two group of patients were selected. Group 1 represents 46 patients that received ovarian-biostimulation monthly for three months. Group 2 represents 32 patients that received… Expand
    ConditionsOvarian Reserve
    InterventionDietary Supplement, Procedure
    INTERVENTIONAL CLINICAL TRIAL
    Women delay maternity and, as a consequence, available oocyte number and their quality decrease (9-18% of all IVF patients). Different treatment protocols have been developped… Expand
    ConditionsOvarian Reserve
    InterventionProcedure
    NEWS ARTICLE
    NEWS ARTICLE
    Female mice lack adult germ-line stem cells but sustain oogenesis using stable primordial follicles
    • 138
    • Highly Influenced
    • PDF
    Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood
    • 648
    • PDF
    Stem cell support of oogenesis in the human.
    • 20
    • Highly Influenced
    • PDF
    Production of offspring from a germline stem cell line derived from neonatal ovaries
    • 441
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 72 REFERENCES
    Meiosis and differentiation of mouse germ cells.
    • 234
    The tao of stem cells in the germline.
    • 109