Germline mutations in the TP53 gene.

@article{Eeles1995GermlineMI,
  title={Germline mutations in the TP53 gene.},
  author={Rosalind A. Eeles},
  journal={Cancer surveys},
  year={1995},
  volume={25},
  pages={101-24}
}
Since the majority of germline mutations in the TP53 gene seem to occur in LFS or LFL families, and these are rare, research is best conducted in a collaborative setting (Li and Fraumeni, in press). In a report from a meeting at Bethesda in 1993, the following areas were outlined for collaborative study: the correlation (if any) of phenotypes with specific mutation; age specific penetrance; cumulative cancer incidence; gender differences in tumour development in carriers; the effects of DNA… CONTINUE READING
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