Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour

Abstract

Wilms tumour is a childhood kidney cancer. Here we identify inactivating CTR9 mutations in 3 of 35 Wilms tumour families, through exome and Sanger sequencing. By contrast, no similar mutations are present in 1,000 population controls (P<0.0001). Each mutation segregates with Wilms tumour in the family and a second mutational event is present in available… (More)
DOI: 10.1038/ncomms5398

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