Germline mutations in BRIP1 and PALB2 in Jewish high cancer risk families


Germline mutations in BRCA1 and BRCA2 account for ~30 % of inherited breast cancer. BRIP1 and PALB2 are likely genes for breast cancer susceptibility, based on their roles in maintaining cellular integrity. Indeed, few pathogenic germline mutations in both genes are reported in ethnically diverse breast cancer families. There is a paucity of data on the… (More)
DOI: 10.1007/s10689-012-9540-8

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