Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk

@article{Xu2002GermlineMA,
  title={Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk},
  author={Jianfeng Xu and S{\'i}qun Lilly Zheng and Akira Komiya and Josyf C Mychaleckyj and Sarah D. Isaacs and Jennifer Hu and David Sterling and Ethan M. Lange and Gregory A Hawkins and Aubrey Turner and Charles M. Ewing and D. Faith and Jill R Johnson and Hiroyoshi Suzuki and Piroska Bujnovszky and Kathleen E. Wiley and Angelo Demarzo and George Steven Bova and Baoli Chang and M. Craig Hall and D L Mccullough and Alan W. Partin and Vahan S. Kassabian and John D. Carpten and Joan E. Bailey-Wilson and Jeffrey M. Trent and Jill A. Ohar and Eugene Bleecker and Patrick Walsh and William B Isaacs and Deborah A. Meyers},
  journal={Nature Genetics},
  year={2002},
  volume={32},
  pages={321-325}
}
Deletions on human chromosome 8p22–23 in prostate cancer cells and linkage studies in families affected with hereditary prostate cancer (HPC) have implicated this region in the development of prostate cancer. The macrophage scavenger receptor 1 gene (MSR1, also known as SR-A) is located at 8p22 and functions in several processes proposed to be relevant to prostate carcinogenesis. Here we report the results of genetic analyses that indicate that mutations in MSR1 may be associated with risk of… CONTINUE READING
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