Germline mutation analysis of BRCA1 and BRCA2 genes in Yugoslav breast/ovarian cancer families.

@article{Papp1999GermlineMA,
  title={Germline mutation analysis of BRCA1 and BRCA2 genes in Yugoslav breast/ovarian cancer families.},
  author={J{\'a}nos Papp and L Raicevic and J Milasin and Bogomir Dimitrijevi{\'c} and Suzana Radulovic and Edith Ol{\'a}h},
  journal={Oncology reports},
  year={1999},
  volume={6 6},
  pages={1435-8}
}
The frequency of germline BRCA1 and BRCA2 mutations was tested in Yugoslav breast and breast/ovarian cancer families using combined heteroduplex/single-strand conformation polymorphism analysis for the entire coding region of both genes. Three different recurrent BRCA1 mutations (one 185delAG, one 3447del4 and two 5382insC) were identified in 4 of 12 families (33%), whereas no definite disease-causing alterations of BRCA2 was detected. Genotype analysis revealed a possible common founder effect… CONTINUE READING

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