Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.

@article{Trevino2009GermlineGV,
  title={Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.},
  author={Lisa R. Trevino and Noriko Shimasaki and Wenjian Yang and John Carl Panetta and Cheng Cheng and Deqing Pei and Diana L. H. Chan and Alex Sparreboom and Kathleen M. Giacomini and Ching-Hon Pui and William E. Evans and Mary V. Relling},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2009},
  volume={27 35},
  pages={5972-8}
}
PURPOSE Methotrexate plasma concentration is related to its clinical effects. Our aim was to identify the genetic basis of interindividual variability in methotrexate pharmacokinetics in children with newly diagnosed acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS We performed a genome-wide analysis of 500,568 germline single-nucleotide polymorphisms (SNPs) to identify how inheritance affects methotrexate plasma disposition among 434 children with ALL who received 3,014 courses of… CONTINUE READING
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