Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: associations with tumor progression, age and human papillomavirus infection.

@article{Joseph2006GermlineGP,
  title={Germline genetic polymorphisms of CYP1A1, GSTM1 and GSTT1 genes in Indian cervical cancer: associations with tumor progression, age and human papillomavirus infection.},
  author={Thomas Joseph and Priya Marie Chacko and R. Browne Wesley and Puthuveetil Govindan Jayaprakash and Francis V. James and Madhavan Radhakrishna Pillai},
  journal={Gynecologic oncology},
  year={2006},
  volume={101 3},
  pages={
          411-7
        }
}
OBJECTIVES Host genetic factors may play a role in human papillomavirus (HPV)-associated tumorigenesis, although the issue continues to be a focus of much debate. Biotransformation is critical in carcinogenic activity of numerous environmental carcinogens. It is therefore possible that polymorphisms of genes producing functional changes in xenobiotic metabolizing enzymes may be susceptible factors in cervical carcinogenesis. This study looked into possible relationships among these factors… CONTINUE READING
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