Germline copy number variants are not associated with globally acquired copy number changes in familial breast tumours

@inproceedings{Walker2012GermlineCN,
  title={Germline copy number variants are not associated with globally acquired copy number changes in familial breast tumours},
  author={Logan C. Walker and Lutz Krause and Amanda B Spurdle and Nicola Waddell},
  booktitle={Breast Cancer Research and Treatment},
  year={2012}
}
A characteristic of sporadic and familial breast tumours is genomic instability, resulting from either inherited mutations in genes that control genome integrity or mutations that are acquired in somatic cells during development. It is well established that abnormal chromosome number and structural changes to chromosomes play an important role in the cause and progression of breast cancer. Familial BRCA1 breast tumours are characterised by basal-like phenotype and high-histological grade which… CONTINUE READING