Germline Stem Cells Anchored by Adherens Junctions in the Drosophila Ovary Niches

@article{Song2002GermlineSC,
  title={Germline Stem Cells Anchored by Adherens Junctions in the Drosophila Ovary Niches},
  author={Xiaoqing Song and C. Zhu and C. Doan and T. Xie},
  journal={Science},
  year={2002},
  volume={296},
  pages={1855 - 1857}
}
  • Xiaoqing Song, C. Zhu, +1 author T. Xie
  • Published 2002
  • Biology, Medicine
  • Science
  • How stem cells are recruited to and maintained in their niches is crucial to understanding their regulation and use in regenerative medicine. Here, we demonstrate that DE-cadherin–mediated cell adhesion is required for anchoring germline stem cells (GSCs) in their niches in the Drosophila ovary. Two major components of this adhesion process, DE-cadherin and Armadillo/β-catenin, accumulate at high levels in the junctions between GSCs and cap cells, one of the niche components. Removal of these… CONTINUE READING

    Topics from this paper.

    Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life
    • 1,555
    • PDF
    Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
    • 1,794
    Stem cell niche: structure and function.
    • 1,103
    • PDF
    Socializing with the Neighbors Stem Cells and Their Niche
    • 1,708
    • PDF
    Mechanisms of Asymmetric Stem Cell Division
    • 858
    • PDF
    The hematopoietic stem cell in its place
    • 432

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 22 REFERENCES