Germline Stem Cells Anchored by Adherens Junctions in the Drosophila Ovary Niches

@article{Song2002GermlineSC,
  title={Germline Stem Cells Anchored by Adherens Junctions in the Drosophila Ovary Niches},
  author={Xiaoqing Song and Chun-hong Zhu and Chuong Doan and T. Xie},
  journal={Science},
  year={2002},
  volume={296},
  pages={1855 - 1857}
}
How stem cells are recruited to and maintained in their niches is crucial to understanding their regulation and use in regenerative medicine. Here, we demonstrate that DE-cadherin–mediated cell adhesion is required for anchoring germline stem cells (GSCs) in their niches in the Drosophila ovary. Two major components of this adhesion process, DE-cadherin and Armadillo/β-catenin, accumulate at high levels in the junctions between GSCs and cap cells, one of the niche components. Removal of these… Expand
DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary
  • Xiaoqing Song, T. Xie
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2002
Stem cells, niches and cadherins: a view from Drosophila
Integrins control the positioning and proliferation of follicle stem cells in the Drosophila ovary
Anchoring stem cells in the niche by cell adhesion molecules
  • R. Xi
  • Biology, Medicine
  • Cell adhesion & migration
  • 2009
Rab11 maintains connections between germline stem cells and niche cells in the Drosophila ovary
Interactions between stem cells and their niche in the Drosophila ovary.
  • T. Xie, X. Song, +4 authors N. Zhang
  • Biology, Medicine
  • Cold Spring Harbor symposia on quantitative biology
  • 2008
Insulin signals control the competence of the Drosophila female germline stem cell niche to respond to Notch ligands.
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