Germline Stem Cells Anchored by Adherens Junctions in the Drosophila Ovary Niches

  title={Germline Stem Cells Anchored by Adherens Junctions in the Drosophila Ovary Niches},
  author={Xiaoqing Song and C. Zhu and C. Doan and T. Xie},
  pages={1855 - 1857}
  • Xiaoqing Song, C. Zhu, +1 author T. Xie
  • Published 2002
  • Biology, Medicine
  • Science
  • How stem cells are recruited to and maintained in their niches is crucial to understanding their regulation and use in regenerative medicine. Here, we demonstrate that DE-cadherin–mediated cell adhesion is required for anchoring germline stem cells (GSCs) in their niches in the Drosophila ovary. Two major components of this adhesion process, DE-cadherin and Armadillo/β-catenin, accumulate at high levels in the junctions between GSCs and cap cells, one of the niche components. Removal of these… CONTINUE READING

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