Germline PAX5 mutations and B cell leukemia


The transcription factor PAX5 is required for normal B cell development and is frequently mutated or deleted in B cell precursor acute lymphoblastic leukemia (B-ALL). A new study demonstrates that germline hypomorphic mutations of PAX5 are associated with susceptibility to B-ALL, implicating PAX5 in a growing list of hematopoietic transcription factors… (More)
DOI: 10.1038/ng.2778


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@article{Hyde2013GermlinePM, title={Germline PAX5 mutations and B cell leukemia}, author={R. Katherine Hyde and Pengyuan Liu}, journal={Nature Genetics}, year={2013}, volume={45}, pages={1104-1105} }