Germline Genetic Variants Disturbing the Let-7/LIN28 Double-Negative Feedback Loop Alter Breast Cancer Susceptibility

@inproceedings{Chen2011GermlineGV,
  title={Germline Genetic Variants Disturbing the Let-7/LIN28 Double-Negative Feedback Loop Alter Breast Cancer Susceptibility},
  author={A X Chen and Ke-Da Yu and Lei Fan and Ji-yu Li and Chen Yang and A Huang and Graham A Colditz},
  booktitle={PLoS genetics},
  year={2011}
}
Previous studies have shown that let-7 can repress the post-transcriptional translation of LIN28, and LIN28 in turn could block the maturation of let-7, forming a double-negative feedback loop. In this study, we investigated the effect of germline genetic variants on regulation of the homeostasis of the let-7/LIN28 loop and breast cancer risk. We initially demonstrated that the T/C variants of rs3811463, a single nucleotide polymorphism (SNP) located near the let-7 binding site in LIN28, could… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Lin28 promotes transformation and is associated with advanced human malignancies

  • SR Viswanathan, JT Powers, W Einhorn, Y Hoshida, TL Ng
  • Nat Genet
  • 2009
Highly Influential
5 Excerpts

Similar Papers

Loading similar papers…