Germline BRCA1 mutations and G/C polymorphism in the 5'-untranslated region of the RAD51 gene in Polish women with breast cancer.

@article{RomanowiczMakowska2005GermlineBM,
  title={Germline BRCA1 mutations and G/C polymorphism in the 5'-untranslated region of the RAD51 gene in Polish women with breast cancer.},
  author={Hanna Romanowicz-Makowska and Beata Smolarz and Andrzej Kulig},
  journal={Polish journal of pathology : official journal of the Polish Society of Pathologists},
  year={2005},
  volume={56 4},
  pages={161-5}
}
Breast cancer is a significant cause of morbidity and mortality in Western countries. In the present work the distribution of genotypes and frequency of alleles of the RAD51 G/C polymorphism and the frequency of BRCA1 germ-line mutations in patients with breast cancer were investigated. One hundred breast cancer women provided blood for mutation analysis. Blood samples from age matched healthy individuals (n=106) served as control. The G/C polymorphism and BRCA1 mutations were determined by PCR… CONTINUE READING

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