Germline BRCA1 mutation analysis in Indian breast/ovarian cancer families.

@article{Kumar2002GermlineBM,
  title={Germline BRCA1 mutation analysis in Indian breast/ovarian cancer families.},
  author={B Vinod Kumar and Smita Lakhotia and Ravindran Ankathil and Jayaprakash Madhavan and Puthuveetil Govindan Jayaprakash and Madhavan Krishnan Nair and Kumaravel Somasundaram},
  journal={Cancer biology & therapy},
  year={2002},
  volume={1 1},
  pages={
          18-21
        }
}
Most of the predisposition to hereditary breast and ovarian cancer has been attributed to inherited defects in two tumor suppressor genes BRCA1 and BRCA2. To explore the contribution of BRCA1 mutations to hereditary breast cancer among Indian women, we examined the coding sequence of the BRCA1 gene in 14 breast cancer patients with a positive family history of breast and/or ovarian cancer. Mutation analysis was carried out using conformation sensitive gel electrophoresis (CSGE) followed by… CONTINUE READING
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