Germinal centers develop oligoclonally.

  title={Germinal centers develop oligoclonally.},
  author={Frans G. M. Kroese and Auk S. Wubbena and H G Seijen and Paul Nieuwenhuis},
  journal={European journal of immunology},
  volume={17 7},
As part of our studies into the role of germinal centers, we investigated whether each de novo generated germinal center (GC) develops from one single GC precursor cell (GCPC, monoclonal development), a few GCPC (oligoclonal development) or from many GCPC (polyclonal development). Thus, lethally (9 Gy) X-irradiated AO (RT1u) rats were reconstituted with 10(8) thoracic duct lymphocytes (TDL) containing mixtures of AO and AO X BN cells in various ratios. The AO TDL were tolerant for AO X BN cells… CONTINUE READING