Germinal center and activated b-cell profiles separate Burkitt lymphoma and diffuse large B-cell lymphoma in AIDS and non-AIDS cases.

@article{Gormley2005GerminalCA,
  title={Germinal center and activated b-cell profiles separate Burkitt lymphoma and diffuse large B-cell lymphoma in AIDS and non-AIDS cases.},
  author={Robert P Gormley and Rashna Madan and Alina E Dulau and Dongsheng Xu and Ecaterina F Tamas and Pritish Bhattacharyya and Aaron Levalley and Xiaonan Xue and Pankaj Kumar and Joseph Sparano and K. H. Ramesh and Venkat R. Pulijaal and Linda A. Cannizzaro and Daniel Walsh and Harry L. Ioachim and Howard Ratech},
  journal={American journal of clinical pathology},
  year={2005},
  volume={124 5},
  pages={790-8}
}
Morphologic features of Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL) overlap. No single phenotypic marker or molecular abnormality is pathognomonic. We tested a panel of 8 germinal center (GC) and activated B-cell (ABC) markers for their ability to separate BL and DLBCL. We diagnosed 16 BL and 39 DLBCL cases from 21 patients with AIDS and 34 without AIDS based on traditional morphologic criteria, Ki-67 proliferative index, and c-myc rearrangement (fluorescence in situ… CONTINUE READING

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