Germinal center B cells recognize antigen through a specialized immune synapse architecture

@inproceedings{Nowosad2016GerminalCB,
  title={Germinal center B cells recognize antigen through a specialized immune synapse architecture},
  author={Carla R. Nowosad and Katelyn M Spillane and Pavel Tolar},
  booktitle={Nature Immunology},
  year={2016}
}
B cell activation is regulated by B cell antigen receptor (BCR) signaling and antigen internalization in immune synapses. Using large-scale imaging across B cell subsets, we found that, in contrast with naive and memory B cells, which gathered antigen toward the synapse center before internalization, germinal center (GC) B cells extracted antigen by a distinct pathway using small peripheral clusters. Both naive and GC B cell synapses required proximal BCR signaling, but GC cells signaled less… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 31 CITATIONS

B cell antigen extraction is regulated by physical properties of antigen-presenting cells

  • The Journal of cell biology
  • 2017
VIEW 4 EXCERPTS
CITES METHODS, BACKGROUND & RESULTS
HIGHLY INFLUENCED

Mechanoimmunology: molecular-scale forces govern immune cell functions

  • Molecular biology of the cell
  • 2018
VIEW 3 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Germinal Center B Cell Dynamics.

VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Similar Papers

Loading similar papers…