Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone.

@article{Kerfoot2011GerminalCB,
  title={Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone.},
  author={Steven M Kerfoot and Gur Yaari and Jaymin R Patel and Kody L Johnson and David Manuel Arenas Gonz{\'a}lez and Steven H. Kleinstein and Ann M. Haberman},
  journal={Immunity},
  year={2011},
  volume={34 6},
  pages={947-60}
}
We identify the interfollicular (IF) zone as the site where germinal center B cell and T follicular helper (Tfh) cell differentiation initiates. For the first 2 days postimmunization, antigen-specific T and B cells remained confined within the IF zone, formed long-lived interactions, and upregulated the transcriptional repressor Bcl6. T cells also acquired the Tfh cell markers CXCR5, PD-1, and GL7. Responding B and T cells migrated to the follicle interior directly from the IF zone, T cell… CONTINUE READING