Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection

@inproceedings{Bannard2013GerminalCC,
  title={Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection},
  author={Oliver M Bannard and Robert M. Horton and Christopher D C Allen and Jinping An and Takashi Nagasawa and Jason G Cyster},
  booktitle={Immunity},
  year={2013}
}
Germinal center (GC) B cells cycle between the dark zone (DZ) and light zone (LZ) during antibody affinity maturation. Whether this movement is necessary for GC function has not been tested. Here we show that CXCR4-deficient GC B cells, which are restricted to the LZ, are gradually outcompeted by WT cells indicating an essential role for DZ access. Remarkably, the transition between DZ centroblast and LZ centrocyte phenotypes occurred independently of positioning. However, CXCR4-deficient cells… CONTINUE READING
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Germinal center

  • G. D. Victora, T. A. Schwickert, +4 authors M. C. Nussenzweig
  • 2010
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