German-Canadian family (family A) with parkinsonism, amyotrophy, and dementia - Longitudinal observations.

  title={German-Canadian family (family A) with parkinsonism, amyotrophy, and dementia - Longitudinal observations.},
  author={Zbigniew K Wszolek and P. Vieregge and Ryan J. Uitti and Thomas Gasser and Osamu Yasuhara and Patrick L. Mcgeer and Katherine Berry and Donald B. Calne and François J. G. Vingerhoets and Christine Klein and Ronald F. Pfeiffer},
  journal={Parkinsonism & related disorders},
  volume={3 3},
Etiology of Parkinson's disease (PD), amyotrophy lateral sclerosis (ALS), and Alzheimer's disease (AD) remains uncertain. Environmental factors probably play a role, but genetic influences may predispose certain individuals to develop each of these major neurodegenerative disorders. We describe our longitudinal observations concerning a Canadian family traced to Northern Germany. Autosornal dominant inheritance has been established. Affected members present with L-dopa responsive parkinsonism… CONTINUE READING
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