Germacranolides from Calea urticifolia.

  title={Germacranolides from Calea urticifolia.},
  author={M. Yamada and N. Matsuura and Hiroto Suzuki and Chihiro Kurosaka and Naoko Hasegawa and M. Ubukata and Toŝhiyuki Tanaka and M. Iinuma},
  volume={65 23},
Four germacranolides, named calealactones A-C and calealactone B [corrected] were isolated from the leaves of Calea urticifolia (Compositae) in addition to three known germacranolides. Their structures were established on the basis of spectroscopic analysis including by 2D NMR spectroscopy. Calealactone C and 2,3-epoxyjuanisulamin displayed potent toxicity to U937 cells. 
Inhibition of Preadipocyte Differentiation by Germacranolides from Calea urticifolia in 3T3-L1 Cells
Results indicate that germacranolides isolated from Calea urticifolia are the specific inhibitors of preadipocyte differentiation. Expand
Computationally aided stereochemical assignment of undescribed bisabolenes from Calea urticifolia.
Three undescribed bisabolenes, named caleanolenes A-C, as well as, three known sesquiterpene lactones 2,3-epoxyjuanislamin, calealactone B,calein C, and the flavonoid acacetin, were isolated from the chloroform extract of the leaves of C. urticifolia. Expand
Cytotoxic sesquiterpene lactones from Campuloclinium macrocephalum (=Eupatorium macrocephalum).
Three undescribed germacranolide sesquiterpene lactones, named macrocephalides A-C, along with known steroids, triterpenes and flavonoids were isolated from the aerial parts of Campuloclinium macrocephalum and exhibited moderate to potent cytotoxic activity. Expand
Anatomical Characters of Leave and Stem of Calea serrata Less., Asteraceae
The present work aimed to study the pharmacobotanical characters of leaves and stems of C. serrata for quality control purposes and found circular shape with six ribs in the stem were important characters, which contributed to the identification of the species. Expand
Bioactive dicaffeoylquinic acid derivatives from the root extract of Calea urticifolia
The results showed that the analgesic activity detected in the root extract of C. urticifolia could be attributed mainly to the mixture of 1 and 2 and to the novel 3,4-O-dicaffeoyl-epi-quinic acid methyl ester, suggesting that the former might be related to their ability as radical scavengers. Expand
Sesquiterpene Lactones from Calea pinnatifida: Absolute Configuration and Structural Requirements for Antitumor Activity
The results are promising and suggest the importance of studying sesquiterpene lactones isolated from C. pinnatifida in terms of antitumor activity, especially considering the effects of α,β-unsaturated carbonyl systems. Expand
The genus Calea L.: A review on traditional uses, phytochemistry, and biological activities
In this review, the literature data up to December 2016 is compiled, furnishing a comprehensive survey about medicinal uses, chemistry, and biological activities from Calea species. Expand
Isolation of Acacetin from Calea urticifolia with Inhibitory Properties against Human Monoamine Oxidase-A and -B.
The binding modes of acacetin at the enzymatic site of MAO-A and -B were predicted through molecular modeling algorithms, illustrating the high importance of ligand interaction with negative and positive free energy regions of the enzyme active site. Expand
The genus Calea L.: A review of isolated compounds and biological activities
The approximately 125 species of the genus Calea L. (Asteraceae) are distributed throughout tropical and subtropical regions of the Americas. Some species have medicinal properties. Based on popularExpand


Neue germacranolide aus Calea urticifolia
Abstract The investigation of Calea urticifolia afforded eight new germacranolides. While five are heliangolides, three are of a new type and have some unusual structural features. The structures areExpand
Biological activities of sesquiterpene lactones
This review summarizes the present knowledge regarding the biological activities of sesquiterpene lactones and their structure-activity relationships and suggests their evolutionary significance in plants as deterrents against herbivores and anti-fungal, anti-bacterial allelopathic agents. Expand
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
  • T. Mosmann
  • Biology, Medicine
  • Journal of immunological methods
  • 1983
A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis. Expand