Germ line transmission and expression of an RNAi cassette in mice generated by a lentiviral vector system

Abstract

We have used a lentiviral delivery system (LentiLox3.7) to generate transgenic mice harbouring RNA interference (RNAi) against the hepatocyte nuclear factor 4 gamma (HNF4γ). HNF4γ is a nuclear receptor with unknown function. Our analyses performed on founder (F0) and first generation (F1) mice revealed mosaicism in F0 founders and a low efficiency of… (More)
DOI: 10.1007/s11248-007-9119-6

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