Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice.

@article{Gaensler1993GermlineTA,
  title={Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice.},
  author={Karin M. L. Gaensler and Masatsugu Kitamura and Yuet Wai Kan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 23},
  pages={11381-5}
}
Sequential expression of the genes of the human beta-globin locus requires the formation of an erythroid-specific chromatin domain spanning > 200 kb. Regulation of this gene family involves both local interactions with proximal cis-acting sequences and long-range interactions with control elements upstream of the locus. To make it possible to analyze the interactions of cis-acting sequences of the human beta-globin locus in their normal spatial and sequence context, we characterized two yeast… CONTINUE READING

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
45 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 45 extracted citations

Similar Papers

Loading similar papers…