Germ-line transcription and methylation status of the TCR-J alpha locus in its accessible configuration.

@article{Villey1997GermlineTA,
  title={Germ-line transcription and methylation status of the TCR-J alpha locus in its accessible configuration.},
  author={Isabelle Villey and Pierre Quartier and Françoise Selz and Jean-Pierre de Villartay},
  journal={European journal of immunology},
  year={1997},
  volume={27 7},
  pages={1619-25}
}
We have generated two in vivo mouse models to study the regulation of DNA accessibility to the V(D)J recombinase machinery in the T cell receptor (TCR)-J alpha locus. In recombination activating gene (RAG)-deficient mice, both injection of a TCR-beta chain transgene (RTB mice) or anti-CD3-epsilon treatment in vivo (RT3 mice) lead to the same phenotype with homogeneous thymocyte populations blocked at the CD4+ CD8+ double positive (DP) stage. At this developmental stage, the TCR-alpha… CONTINUE READING

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