Germ-line p53-targeted disruption inhibits helicobacter-induced premalignant lesions and invasive gastric carcinoma through down-regulation of Th1 proinflammatory responses.

@article{Fox2002GermlinePD,
  title={Germ-line p53-targeted disruption inhibits helicobacter-induced premalignant lesions and invasive gastric carcinoma through down-regulation of Th1 proinflammatory responses.},
  author={James G Fox and Barbara J. Sheppard and Charles A. Dangler and Mark T. Whary and Melanie Ihrig and Timothy C Wang},
  journal={Cancer research},
  year={2002},
  volume={62 3},
  pages={696-702}
}
p53 is a tumor suppressor gene that is mutated in many human malignancies, including gastric cancer. It remains unclear why patients with germ-line p53 mutations (i.e., Li-Fraumeni syndrome) are not at increased risk for gastric adenocarcinoma, despite the fact that they show a high rate of many other tumors. Furthermore, the precise relationship between germ-line p53 mutations and the response to chronic bacterial infections (such as Helicobacter spp.) has not been investigated. To assess the… CONTINUE READING
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