Germ-line intrachromosomal recombination restores fertility in transgenic MyK-103 male mice.

Abstract

Males of the MyK-103 line of transgenic mice are fertile and sire litters of normal size, but they never transmit the transgene, whereas females transmit the transgene with normal frequency. The chromosome originally bearing the transgene can be transmitted through the male germ line, but only after the transgene is deleted or rearranged by intrachromosomal… (More)

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@article{Wilkie1991GermlineIR, title={Germ-line intrachromosomal recombination restores fertility in transgenic MyK-103 male mice.}, author={Thomas M. Wilkie and Ralf-Peter Braun and Walter Ehrman and Russell Palmiter and Ruediger Hammer}, journal={Genes & development}, year={1991}, volume={5 1}, pages={38-48} }