Germ cell specific protein VASA is over-expressed in epithelial ovarian cancer and disrupts DNA damage-induced G2 checkpoint.

@article{Hashimoto2008GermCS,
  title={Germ cell specific protein VASA is over-expressed in epithelial ovarian cancer and disrupts DNA damage-induced G2 checkpoint.},
  author={Hisashi Hashimoto and Tamotsu Sudo and Yoshiki Mikami and Mieko Otani and Masaoki Takano and Hiroshi Tsuda and Hiroaki Itamochi and Hidetaka Katabuchi and Masayuki Ito and Ryuichiro Nishimura},
  journal={Gynecologic oncology},
  year={2008},
  volume={111 2},
  pages={
          312-9
        }
}
OBJECTIVE Cancer cells have characteristics, such as high telomerase activity and high levels of migration activity and proliferation, which are very similar to those of germ cell lineages. In this study, we examined the expression of VASA, a germ cell lineage specific marker and evaluated its clinical significance in epithelial ovarian cancer (EOC). METHODS We investigated VASA expression in 75 EOC tissues by immunohistochemistry, correlating results with clinicopathological factors. To… CONTINUE READING
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