Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout mice.

@article{Tay2001GermCD,
  title={Germ cell differentiation and synaptonemal complex formation are disrupted in CPEB knockout mice.},
  author={Joyce Tay and Joel D. Richter},
  journal={Developmental cell},
  year={2001},
  volume={1 2},
  pages={201-13}
}
CPEB is a sequence-specific RNA binding protein that regulates translation during vertebrate oocyte maturation. Adult female CPEB knockout mice contained vestigial ovaries that were devoid of oocytes; ovaries from mid-gestation embryos contained oocytes that were arrested at the pachytene stage. Male CPEB null mice also contained germ cells arrested at pachytene. The germ cells from the knockout mice harbored fragmented chromatin, suggesting a possible defect in homologous chromosome adhesion… CONTINUE READING