Germ cell cancer and disorders of spermatogenesis: an environmental connection?

@article{Skakkebaek1998GermCC,
  title={Germ cell cancer and disorders of spermatogenesis: an environmental connection?},
  author={Niels Erik Skakkebaek and Ewa Rajpert-De Meyts and Niels J\orgensen and Elisabeth Carlsen and Peter Meidahl Petersen and Alexander Giwercman and Anne Grethe Andersen and Tina Kold Jensen and Anna Maria Andersson and J\orn M{\"u}ller},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  year={1998},
  volume={106 1},
  pages={3-11; discussion 12}
}
Why is there a small peak of germ cell tumours in the postnatal period and a major peak in young age, starting at puberty? And, paradoxically, small risk in old age, although spermatogenesis is a lifelong process? Why is this type of cancer more common in individuals with maldeveloped gonads, including undescended testis, gonadal dysgenesis and androgen insensitivity syndrome? Why has there, during the past 50 years, been a quite dramatic increase in testicular cancer in many developed… CONTINUE READING