Geriatric muscle stem cells switch reversible quiescence into senescence

@article{SousaVictor2014GeriatricMS,
  title={Geriatric muscle stem cells switch reversible quiescence into senescence},
  author={Pedro Sousa‐Victor and Susana Gutarra and Laura Garcia-Prat and Javier Rodr{\'i}guez-Ubreva and Laura Ortet and Vanessa Ruiz-Bonilla and Merc{\`e} Jard{\'i} and Esteban Ballestar and Susana Gonz{\'a}lez and Antonio L. Serrano and Eusebio Perdiguero and Pura Mu{\~n}oz-C{\'a}noves},
  journal={Nature},
  year={2014},
  volume={506},
  pages={316-321}
}
Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline with ageing. Here we report that geriatric satellite cells are incapable of maintaining their normal quiescent state in muscle homeostatic conditions, and that this irreversibly affects their intrinsic regenerative and self-renewal capacities. In geriatric mice, resting satellite cells lose reversible quiescence by… 

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