Geriatric muscle stem cells switch reversible quiescence into senescence

@article{SousaVictor2014GeriatricMS,
  title={Geriatric muscle stem cells switch reversible quiescence into senescence},
  author={Pedro Sousa‐Victor and Susana Gutarra and Laura Garcia-Prat and Javier Rodr{\'i}guez-Ubreva and Laura Ortet and Vanessa Ruiz-Bonilla and Merc{\`e} Jard{\'i} and Esteban Ballestar and Susana Gonz{\'a}lez and Antonio L. Serrano and Eusebio Perdiguero and Pura Mu{\~n}oz-C{\'a}noves},
  journal={Nature},
  year={2014},
  volume={506},
  pages={316-321}
}
Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline with ageing. Here we report that geriatric satellite cells are incapable of maintaining their normal quiescent state in muscle homeostatic conditions, and that this irreversibly affects their intrinsic regenerative and self-renewal capacities. In geriatric mice, resting satellite cells lose reversible quiescence by… 

Geroconversion of aged muscle stem cells under regenerative pressure

How cellular senescence may be a common mechanism of stem cell aging at the organism level is discussed and induction of p16INK4a in young muscle stem cells through deletion of the Polycomb complex protein Bmi1 recapitulates the geriatric phenotype is shown.

Ageing: Genetic rejuvenation of old muscle

Pura Munoz-Canoves and colleagues show that ageing satellite cells undergo an irreversible transition from quiescence to a pre-senescence state associated with increased expression of p16INK4a, a tumour-suppressor protein that has been identified as a marker for senescence.

Autophagy maintains stemness by preventing senescence

It is reported that basal autophagy is essential to maintain the stem-cell quiescent state in mice and revealed to be a decisive stem- cell-fate regulator, with implications for fostering muscle regeneration in sarcopenia.

Rejuvenating Muscle Stem Cell Function: Restoring Quiescence and Overcoming Senescence.

A unifying hypothesis posits that in aging humans, first loss of quiescence occurs, depleting the stem cell population, but that remaining SMSCs are increasingly subject to presenescence in the very old.

Satellite cells in ageing: use it or lose it

This review examines how periodic activation and cycling of satellite cells through exercise can mitigate senescence acquisition and myogenic decline in aged muscle.

New mechanisms driving muscle stem cell regenerative decline with aging.

Recent research into how intracellular networks control stem cell function and how their dysregulation contributes to aging is reviewed, with a particular focus on senescence entry in extreme old age.

Control of satellite cell function in muscle regeneration and its disruption in ageing

The role and regulation of satellite cells in skeletal muscle homeostasis and regeneration is discussed, including the cell-intrinsic control of quiescence versus activation, the importance of satellite cell–niche communication, and deregulation of these mechanisms associated with ageing.

Sestrins regulate age-induced deterioration of muscle stem cell homeostasis

It is shown that Sestrin1,2 loss results in hyperactivation of the mTORC1 complex, increased propensity to enter the cell cycle and shifts in metabolic flux, and in young mice, Sestrins are dispensable for regenerative responses of MuSCs.

A Long Journey before Cycling: Regulation of Quiescence Exit in Adult Muscle Satellite Cells

This review summarizes key events that occur during quiescence exit in MuSCs and discusses the molecular regulation of this process with an emphasis on multiple levels of intrinsic regulatory mechanisms.
...

References

SHOWING 1-10 OF 53 REFERENCES

The aged niche disrupts muscle stem cell quiescence

It is demonstrated that the aged muscle stem cell niche, the muscle fibre, expresses Fgf2 under homeostatic conditions, driving a subset of satellite cells to break quiescence and lose their self-renewing capacity.

Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells

The current literature on the coordinated relationship between cell extrinsic and intrinsic factors that regulate the function of satellite cells, and ultimately determine tissue homeostasis and repair during aging, is reviewed to encourage the search for new anti‐aging strategies.

Maintenance of muscle stem cell quiescence by microRNA-489

Evidence is provided of the miRNA pathway in general, and of a specific miRNA, miR-489, in actively maintaining the quiescent state of an adult stem-cell population, as it functions as a regulator of satellite-cell quiescence.

Skeletal muscle stem cells: effects of aging and metabolism on muscle regenerative function.

Recent and emerging insights into the molecular and biochemical signals that control satellite cell function are reviewed and discussed in the context of muscle degenerative diseases such as dystrophy and sarcopenia.

Satellite cells and the muscle stem cell niche.

For the last half century, the advance of molecular biology, cell biology, and genetics has greatly improved the understanding of skeletal muscle biology, with focuses on functions of satellite cells and their niche during the process ofletal muscle regeneration.

Molecular regulation of stem cell quiescence

Deciphering the molecular mechanisms regulating adult stem cell quiescence will increase the understanding of tissue regeneration mechanisms and how they are dysregulated in pathological conditions and in ageing.
...