Geranylgeranylacetone suppresses hydrogen peroxide-induced apoptosis of osteoarthritic chondrocytes.

  title={Geranylgeranylacetone suppresses hydrogen peroxide-induced apoptosis of osteoarthritic chondrocytes.},
  author={Masaki Yoda and Tadahiro Sakai and Hirohito Mitsuyama and Hideki Hiraiwa and Naoki Ishiguro},
  journal={Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association},
  volume={16 6},
BACKGROUND Osteoarthritis (OA) is a common disease, afflicting many sufferers with both pain and functional disorders. Various therapies have been attempted for OA, but no fully effective treatment has been established yet. Apoptosis of chondrocytes caused by reactive oxygen species (ROS) has been considered important in the pathogenesis of OA. The progression of OA may be prevented by suppressing apoptosis of chondrocytes. Geranylgeranylacetone (GGA) has been used as an anti-ulcer drug in… CONTINUE READING


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