Geranylgeranylacetone has anti-hepatitis C virus activity via activation of mTOR in human hepatoma cells

@article{Takeshita2011GeranylgeranylacetoneHA,
  title={Geranylgeranylacetone has anti-hepatitis C virus activity via activation of mTOR in human hepatoma cells},
  author={Shigeyuki Takeshita and Tatsuki Ichikawa and Naota Taura and Hisamitsu Miyaaki and Toshihisa Matsuzaki and Masashi Otani and Toru Muraoka and Motohisa Akiyama and Satoshi Miuma and Eisuke Ozawa and Masanori Ikeda and Nobuyuki Kato and Hajime Isomoto and Fuminao Takeshima and Kazuhiko Nakao},
  journal={Journal of Gastroenterology},
  year={2011},
  volume={47},
  pages={195-202}
}
Geranylgeranylacetone (GGA), an isoprenoid compound which includes retinoids, has been used orally as an anti-ulcer drug in Japan. GGA acts as a potent inducer of anti-viral gene expression by stimulating ISGF3 formation in human hepatoma cells. This drug has few side effects and reinforces the effect of IFN when administered in combination with peg-IFN and ribavirin. This study verified the anti-HCV activity of GGA in a replicon system. In addition, mechanisms of anti-HCV activity were… CONTINUE READING
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