Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70.

@article{Suzuki2005GeranylgeranylacetoneAI,
  title={Geranylgeranylacetone ameliorates ischemic acute renal failure via induction of Hsp70.},
  author={Satoshi Suzuki and Shoichi Maruyama and Waichi Sato and Yoshiki Morita and Fumihiko Sato and Yusuke Miki and Sawako Kato and Masahisa Katsuno and Gen Sobue and Yukio Yuzawa and Seiichi Matsuo},
  journal={Kidney international},
  year={2005},
  volume={67 6},
  pages={2210-20}
}
BACKGROUND Heat shock proteins (HSPs) are well known as cytoprotective proteins. Geranylgeranylacetone (GGA), an antiulcer agent, has recently been shown to induce Hsp70. This study was performed to investigate the renoprotective properties of GGA. METHODS The effect of GGA on the induction of the major HSPs (Hsp90, Hsp70, Hsc70, Hsp60, and Hsp32) was studied in the rat kidney or rat primary cultures of tubular epithelial cells (R-TECs) by Western blot. Localization of Hsp70 was determined by… CONTINUE READING

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Geranylgeranylacetone ( GGA ) , an antiulcer agent , has recently been shown to induce Hsp70 .
Blood urea nitrogen ( BUN ) and serum creatinine was also measured .
The cytoprotective properties of GGA were also studied in vitro by treating R - TECs with GGA ( 10 mumol / L ) or a vehicle , followed by incubation in culture medium with oxidative stress condition ( 0.5 mmol / L hydrogen peroxide ) or ischemic condition ( 2 nmol / L NaCN and 20 mmol / L 2-deoxyglucose in the absence of medium glucose ) .
The cytoprotective properties of GGA were also studied in vitro by treating R - TECs with GGA ( 10 mumol / L ) or a vehicle , followed by incubation in culture medium with oxidative stress condition ( 0.5 mmol / L hydrogen peroxide ) or ischemic condition ( 2 nmol / L NaCN and 20 mmol / L 2-deoxyglucose in the absence of medium glucose ) .
The present study suggests that GGA would be a useful tool in treating acute renal failure or preventing transplanted kidney damage in the clinical setting .
The present study suggests that GGA would be a useful tool in treating acute renal failure or preventing transplanted kidney damage in the clinical setting .
The present study suggests that GGA would be a useful tool in treating acute renal failure or preventing transplanted kidney damage in the clinical setting .
Geranylgeranylacetone ( GGA ) , an antiulcer agent , has recently been shown to induce Hsp70 .
Blood urea nitrogen ( BUN ) and serum creatinine was also measured .
The present study suggests that GGA would be a useful tool in treating acute renal failure or preventing transplanted kidney damage in the clinical setting .
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