Geranylgeranylacetone Suppresses N-Methyl-N-nitrosourea-Induced Photoreceptor Cell Loss in Mice.

  title={Geranylgeranylacetone Suppresses N-Methyl-N-nitrosourea-Induced Photoreceptor Cell Loss in Mice.},
  author={Yoshiki Koriyama and Kazuhiro Ogai and Kayo Sugitani and Suguru Hisano and Satoru Kato},
  journal={Advances in experimental medicine and biology},
Retinitis pigmentosa is a disease characterized by the loss of photoreceptor cells. The N-methyl-N-nitrosourea (MNU)-induced retinal degeneration model is widely used to study the mechanism of these retinal degenerative disorders because of its selective photoreceptor cell death. As for the cell death mechanism of MNU, calcium-calpain activation and lipid peroxidation processes are involved in the initiation of this cell death. Although such molecular mechanisms of the MNU-induced cell death… 

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Hsp70.1 and related lysosomal factors for necrotic neuronal death

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Role of oxidative stress in retinal photoreceptor cell death in N-methyl-N-nitrosourea-treated mice.

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Heat shock protein 70 induction by valproic acid delays photoreceptor cell death by N‐methyl‐N‐nitrosourea in mice

HSP70 induction by valproic acid was dually effective against MNU‐induced photoreceptor cell loss as a result of its anti‐apoptotic actions and its ability to prevent HSP70 degradation, which might help lead to a better understanding of the pathogenic mechanism of RDs.