Geranylgeranylacetone Protects Cultured Guinea Pig Gastric Mucosal Cells from Indomethacin

  title={Geranylgeranylacetone Protects Cultured Guinea Pig Gastric Mucosal Cells from Indomethacin},
  author={Wataru Tomisato and Naoko Takahashi and Chiho Komoto and Kazuhito Rokutan and Tomofusa Tsuchiya and Tohru Mizushima},
  journal={Digestive Diseases and Sciences},
One of the major side effects of nonsteroidal antiinflammatory drugs, such as indomethacin, is gastropathy. The purpose of this study was to search for a therapeutic drug to prevent this side effect in vitro. We found that geranylgeranylacetone, a unique antiulcer drug with a heat-shock protein-inducing ability, protected cultured guinea pig gastric mucosal cells from cell damage caused by indomethacin. This cytoprotective effect of geranylgeranylacetone required concentrations of more than 10… CONTINUE READING
14 Citations
23 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 14 extracted citations


Publications referenced by this paper.
Showing 1-10 of 23 references

Similar Papers

Loading similar papers…