Geranylgeranylacetone Protects Cultured Guinea Pig Gastric Mucosal Cells from Indomethacin

@article{Tomisato2000GeranylgeranylacetonePC,
  title={Geranylgeranylacetone Protects Cultured Guinea Pig Gastric Mucosal Cells from Indomethacin},
  author={Wataru Tomisato and Naoko Takahashi and Chiho Komoto and Kazuhito Rokutan and Tomofusa Tsuchiya and Tohru Mizushima},
  journal={Digestive Diseases and Sciences},
  year={2000},
  volume={45},
  pages={1674-1679}
}
One of the major side effects of nonsteroidal antiinflammatory drugs, such as indomethacin, is gastropathy. The purpose of this study was to search for a therapeutic drug to prevent this side effect in vitro. We found that geranylgeranylacetone, a unique antiulcer drug with a heat-shock protein-inducing ability, protected cultured guinea pig gastric mucosal cells from cell damage caused by indomethacin. This cytoprotective effect of geranylgeranylacetone required concentrations of more than 10… CONTINUE READING
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