Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation

@article{Agabiti2017GeranylgeranylDS,
  title={Geranylgeranyl diphosphate synthase inhibition induces apoptosis that is dependent upon GGPP depletion, ERK phosphorylation and caspase activation},
  author={S. Agabiti and Jin Li and A. Wiemer},
  journal={Cell Death \& Disease},
  year={2017},
  volume={8}
}
Bisphosphonates are diphosphate analogs that inhibit the intermediate enzymes of the mevalonate pathway. Here, we compared the effects of a farnesyl diphosphate synthase inhibitor, zoledronate, and a geranylgeranyl diphosphate synthase (GGDPS) inhibitor, digeranyl bisphosphonate (DGBP), on lymphocytic leukemia cell proliferation and apoptosis. Both zoledronate and DGBP inhibited proliferation with DGBP doing so more potently. DGBP was markedly less toxic than zoledronate toward the viability of… Expand
RhoA: a dubious molecule in cardiac pathophysiology

References

SHOWING 1-10 OF 67 REFERENCES
Bisphosphonates Induce Autophagy by Depleting Geranylgeranyl Diphosphate
Nitrogen‐Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post‐Translational Prenylation of GTP‐Binding Proteins, Including Ras
Zoledronic acid induces apoptosis and S-phase arrest in mesothelioma through inhibiting Rab family proteins and topoisomerase II actions
Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates.
...
1
2
3
4
5
...