Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U937 cells.

@article{Masuda1997GeranylgeraniolPI,
  title={Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U937 cells.},
  author={Yoshito Masuda and Mako Nakaya and Shigeo Nakajo and Kazuyasu Nakaya},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={234 3},
  pages={641-5}
}
In a previous study, we showed that geranylgeraniol (GGO) is a potent inducer of apoptosis in human leukemia cells. The present study describes the effects of GGO on the activity of cysteine-dependent aspartate-directed proteases (caspases) in human leukemia U937 cells. The caspase-3 (CPP32) activity was increased in a time-dependent manner by treatment with 50 microM GGO, whereas no activation of caspase-1 (interleukin-1beta converting enzyme (ICE)) was observed in any time period under the… CONTINUE READING