Geraniol rescues inflammation in cellular and animal models of mevalonate kinase deficiency.

Abstract

BACKGROUND/AIM The inhibition of the mevalonate pathway through genetic defects such as mevalonate kinase deficiency (MKD) or pharmacological drugs such as aminobisphosphonates causes a shortage of intermediate compounds, in particular geranylgeranyl-pyrophosphate (GGPP), which is associated with the consequent augmented IL-1β release in monocytes… (More)

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