Geraniol, a component of plant essential oils, sensitizes human colonic cancer cells to 5-Fluorouracil treatment.

@article{Carnsecchi2002GeraniolAC,
  title={Geraniol, a component of plant essential oils, sensitizes human colonic cancer cells to 5-Fluorouracil treatment.},
  author={St{\'e}phanie Carn{\'e}secchi and Keith Langley and Françoise Exinger and Francine Goss{\'e} and F Guerrero Raul},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={301 2},
  pages={
          625-30
        }
}
Differentiation of human colonic cancer cells at confluency has been correlated to their increased resistance to chemotherapeutic agents. The aim of this study was to determine whether blocking Caco-2 cell differentiation could sensitize the cells to 5-fluorouracil (5-FU) treatment. We show that in cells at confluency, geraniol (400 microM) prevented the formation of brush-border membranes and inhibited the expression of intestinal hydrolases (sucrase, lactase, alkaline phosphatase). The… CONTINUE READING
Tweets
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 26 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

Similar Papers

Loading similar papers…