Geraniol, a component of plant essential oils, sensitizes human colonic cancer cells to 5-Fluorouracil treatment.

@article{Carnsecchi2002GeraniolAC,
  title={Geraniol, a component of plant essential oils, sensitizes human colonic cancer cells to 5-Fluorouracil treatment.},
  author={S. Carn{\'e}secchi and K. Langley and F. Exinger and F. Goss{\'e} and F. Raul},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={301 2},
  pages={
          625-30
        }
}
  • S. Carnésecchi, K. Langley, +2 authors F. Raul
  • Published 2002
  • Medicine, Chemistry
  • The Journal of pharmacology and experimental therapeutics
  • Differentiation of human colonic cancer cells at confluency has been correlated to their increased resistance to chemotherapeutic agents. The aim of this study was to determine whether blocking Caco-2 cell differentiation could sensitize the cells to 5-fluorouracil (5-FU) treatment. We show that in cells at confluency, geraniol (400 microM) prevented the formation of brush-border membranes and inhibited the expression of intestinal hydrolases (sucrase, lactase, alkaline phosphatase). The… CONTINUE READING
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