Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway.

@article{Wang2015GeraniinEC,
  title={Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway.},
  author={Peng Wang and Xiao lin Peng and Zuo-fu Wei and Fu-Yao Wei and Wei Wang and Wei-Dong Ma and Li-ping Yao and Yu-Jie Fu and Yuan-gang Zu},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1850 9},
  pages={1751-61}
}
BACKGROUND Geraniin, an active compound with remarkable antioxidant activity, was isolated from Geranium sibiricum. The present study aimed to investigate whether geraniin has the ability to activate Nrf2, induce antioxidant enzyme expression and protect cells from oxidative damage. METHODS The cells were pretreated with geraniin for 24h and exposed to hydrogen peroxide (H₂O₂) for 4h. Intracellular reactive oxygen species (ROS) levels, mitochondrial membrane potential and apoptosis were… CONTINUE READING
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