Gephyrin-independent clustering of postsynaptic GABA(A) receptor subtypes.

  title={Gephyrin-independent clustering of postsynaptic GABA(A) receptor subtypes.},
  author={Matthias Kneussel and Johann Helmut Brandst{\"a}tter and Bruno Gasnier and Guoping Feng and Joshua R Sanes and Heinrich Betz},
  journal={Molecular and cellular neurosciences},
  volume={17 6},
Gephyrin has been shown to be essential for the synaptic localization of the inhibitory glycine receptor and major GABA(A) receptor (GABA(A)R) subtypes. However, in retina certain GABA(A)R subunits are found at synaptic sites in the absence of gephyrin. Here, we quantitatively analyzed GABA(A)R alpha1, alpha2, alpha3, alpha5, beta2/3, and gamma2 subunit immunoreactivities in spinal cord sections derived from wild-type and gephyrin-deficient (geph -/-) mice. The punctate staining of GABA(A)R… CONTINUE READING
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