Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons

@article{Kirsch1993GephyrinAO,
  title={Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons},
  author={Joachim Kirsch and I. Wolters and Antoine Triller and Heinrich Betz},
  journal={Nature},
  year={1993},
  volume={366},
  pages={745-748}
}
EACH neuron in the mammalian brain carries many postsynaptic membrane specializations containing high densities of receptors that mediate signal transduction upon neurotransmitter release from the apposed nerve terminal1. Little is known about the mechanisms by which receptors are transported to and anchored at postsynaptic sites, but extracellular2 as well as intracellular3 components may be involved. Ultrastructural studies have shown that the peripheral membrane protein gephyrin4, which co… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 145 extracted citations

Similar Papers

Loading similar papers…