Georgia: an unlikely stronghold for bacteriophage therapy

  title={Georgia: an unlikely stronghold for bacteriophage therapy},
  author={Tom Parfitt},
  journal={The Lancet},
  • T. Parfitt
  • Published 25 June 2005
  • Medicine
  • The Lancet

Biocommunication of Phages

Diverse competences of phages show that they process and evaluate available information and then modify their behaviour accordingly, and that this capacity to evaluate information is possible owing to communication processes within phages, between phage species (intra-organismic), and between phages and non-phage organisms (trans Organismic).

Exploiting bacteriophages to tackle Clostridium difficile infection

A continuous model of CDI in a colon model was successfully produced and demonstrated variable efficacy rates from no apparent decrease in the burden of C. difficile to a reduction to below the limit of detection by culture, with no detrimental effect on commensal microbiota.

Enhancing the Stability of Bacteriophages Using Physical, Chemical, and Nano-Based Approaches: A Review

Various formulations that impart stability to phage stocks are described, mainly focusing on polymer-based stabilization, encapsulation, lyophilization, and nano-assisted solutions.

The power of unbiased phenotypic screens – cellulose as a first receptor for the Schitoviridae phage S6 of Erwinia amylovora

The biofilm extracellular matrix component cellulose has been identified as a cyclic di‐GMP dependent first receptor required for infection with the phage to possess beta‐1,4‐glucosidases to degrade the exopolysaccharide, which allows maintenance of a phage‐microbe equilibrium with a low bacterial density.

Antibacterial Hydrogels Derived from Poly(γ-glutamic acid) Nanofibers

Biocompatible hydrogels with antibacterial properties derived from γ-polyglutamic acid (γ-PGA) were prepared from bulk and electrospun nanofibers. The antibacterial drugs loaded in these hydrogels

Phages for Africa: The Potential Benefit and Challenges of Phage Therapy for the Livestock Sector in Sub-Saharan Africa

The underlying problems of antibiotic use and resistance associated with livestock farming in SSA, bacteriophages as a suitable alternative, what attributes contribute to making bacteriophile potentially valuable for SSA and recent research on bacteriaphages in Africa are reviewed.

Gold—Polyoxoborates Nanocomposite Prohibits Adsorption of Bacteriophages on Inner Surfaces of Polypropylene Labware and Protects Samples from Bacterial and Yeast Infections

It is shown that a BOA nanocomposite deposited onto the inner walls of the containers stabilizes phage suspensions against uncontrolled adsorption and titer decrease and provides antibacterial and antifungal protection.

Phage Therapy in Livestock and Companion Animals

The main recent studies on phage therapy in livestock and companion animals are summarized, providing an insight into current advances in this area and the future of treatments for bacterial infections.

Resistance and Adaptation of Bacteria to Non-Antibiotic Antibacterial Agents: Physical Stressors, Nanoparticles, and Bacteriophages

A detailed overview of how bacteria acquire resistance against non-antibiotic factors is provided and innate bacterial defense systems and how bacteriophages have evolved to tackle them are discussed.

Acid and aluminium-tolerant microbes isolated from China space station assembly cleanroom surfaces and identified by 16S rRNA/ITS sequencing and MALDI-TOF MS

Al and acid-tolerant microbes were isolated from the samples of China space station assembly cleanroom surfaces; acidic environments can accelerate the corrosion process on metal surfaces.