George Emil Palade: charismatic virtuoso of cell biology

  title={George Emil Palade: charismatic virtuoso of cell biology},
  author={Alan Michael Tartakoff},
  journal={Nature Reviews Molecular Cell Biology},
  • A. Tartakoff
  • Published 1 November 2002
  • Biology
  • Nature Reviews Molecular Cell Biology
George Palade has created, shared and passed on a multidisciplinary view of the functional organization, biogenesis and dynamics of organelles. His open-mindedness and tenacity, along with his rigour and sense of intellectual elegance, have been remarkable. This focus on the logic of organelles defined a crucial turning point in biomedical science. The following article sketches Palade's research, as part of a larger community that flourished after the Second World War. 

George Emil Palade: charismatic virtuoso of cell biology

  • A. Tartakoff
  • Education
    Nature Reviews Molecular Cell Biology
  • 2003
Nature Rev. Mol. Cell Biol. 3, 871–876 (2002) There is an article (November 2002) associated with this correction. Please click here to view it. The author would like to make the following

George Emil Palade: How Sucrose and Electron Microscopy Led to the Birth of Cell Biology

George Emil Palade developed the “sucrose method” for homogenation and fractionation of liver tissue with Hogeboom and Schneider and was able to isolate and characterize intact mitochondria for the first time.

A man for all seasons: reflections on the life and legacy of George Palade.

  • M. Farquhar
  • Biology
    Annual review of cell and developmental biology
  • 2012
The scientific career of George E. Palade is reviewed, the man many consider to be the father of cell biology, who is best known for his discovery of ribosomes, for establishing their role in protein synthesis, and for delineation of the secretory pathway.

The big and intricate dreams of little organelles: Embracing complexity in the study of membrane traffic

Systematic approaches that revealed remarkable insight into the complexity of organelle dynamics and membrane traffic are discussed, including the use of proximity‐based proteomics, high‐throughput imaging, transcriptomics and computational modeling.

A tribute to George E. Palade.

  • J. Jamieson
  • Medicine
    The Journal of clinical investigation
  • 2008
George E. Palade’s scientific contributions, which spanned nearly 50 years, led to a fundamental understanding of the structure and function of cells and defined the new field of cell biology, which opened novel areas of research that countless scientists in diverse fields now explore.

History of the Department of Cell Biology at Yale School of Medicine, 1813-2010

  • T. Lentz
  • Biology
    The Yale journal of biology and medicine
  • 2011
The history of the Department of Anatomy at Yale and its evolution into Cell Biology that began with the introduction of histology into the curriculum in the 1860s is reviewed.

Identification of coronavirus particles by electron microscopy requires demonstration of specific ultrastructural features

The authors report detection of SARS-CoV-2 virions within alveolar type 2 cells of representative COVID-19 cases and three electron micrographs show putative virus particles, indicated by arrows, to document their findings.

Vesicles versus Tubes: Is Endoplasmic Reticulum-Golgi Transport in Plants Fundamentally Different from Other Eukaryotes?1

Four leading cell biologists reflect on the controversial nature of the vector for transport between the ER and Golgi apparatus in higher plants, and introduces the reader to possible alternatives to vesicles or tubules, which are now emerging as a result of exciting new developments in high-resolution light microscopy in yeast.

Exploring eponyms in a corpus of medical articles. Origins and meanings

This study investigates a corpus of randomly chosen articles form a Romanian medical journal published in English and included in the Core Collection of Clarivate Analytics to identify the occurrences of eponyms and, consequently, to trace their origin and explain their meaning.

The Legacy of a Founding Father of Modern Cell Biology: George Emil Palade (1912-2008)

An overview of Palade’s seminal research is provided in the context of the early developments in the field of modern cell biology.



George E. Palade: charting the secretory pathway.

The Mitochondrion: Molecular Basis of Structure and Function

The many discussions of the relation of structure and function in mitochondria, the cytoplasmic "power plants" of aerobic cells, form one of the most exciting aspects of the book.

Recollections on the Beginnings of The Journal of Cell Biology

The first laboratory of cell biology was established at the Catholic University of Louvain, Belgium, in 1876, and it is surprising that the term "cell biology" was still available for the journal title in 1962.

The coming of age of the cell.

Inventory of living mechanisms by cell fractionation, biochemistry, and electron microscopy, and a view of the impact of the findings on our status and thinking.


  • K. Porter
  • Biology
    The Journal of biophysical and biochemical cytology
  • 1956
Electron microscopy of thin sections of muscle fibers in myotomes of Amblystoma larvae has revealed the presence of a complex, membrane-limited system of canaliculi and vesicles which form a lace-like reticulum around and among the myofibrils which seems appropriate to assign to the system a role in the conduction of the excitatory impulse.

Intracellular aspects of the process of protein synthesis.

The title of the Nobel Lecture of George Palade (1 August, p. 347) should have been "Intracellular aspects of the process of protein secretion."


Results strongly suggest that new membrane is synthesized in the rough ER and subsequently transferred to the smooth ER in rat hepatocytes during a period of rapid cell differentiation.

BIOGENESIS OF ENDOPLASMIC RETICULUM MEMBRANES I. Structural and Chemical Differentiation in Developing Rat Hepatocyte

Results strongly suggest that new membrane is synthesized in the rough ER and subsequently transferred to the smooth ER in rat hepatocytes during a period of rapid cell differentiation.

Differentiated microdomains on the luminal surface of the capillary endothelium. I. Preferential distribution of anionic sites

Cationized ferritin binds preferentially to certain microdomains of the luminal plasmalemma of fenestrated capillaries (mouse pancreas and jejunum) and the functional implications of the association of these micro Domains with structures involved in capillary permeability are discussed.