Geometrically constrained analogues of N-benzylindolylglyoxylylamides: [1, 2, 4]triazino[4, 3-a]benzimidazol-4(10H)-one derivatives as potential new ligands at the benzodiazepine receptor.

@article{Primofiore2003GeometricallyCA,
  title={Geometrically constrained analogues of N-benzylindolylglyoxylylamides: [1, 2, 4]triazino[4, 3-a]benzimidazol-4(10H)-one derivatives as potential new ligands at the benzodiazepine receptor.},
  author={Giampaolo Primofiore and Federico da Settimo and Sabrina Taliani and Anna Maria Marini and Francesca Simorini and Ettore Novellino and Giovanni Greco and Letizia Trincavelli and Claudia Martini},
  journal={Archiv der Pharmazie},
  year={2003},
  volume={336 9},
  pages={413-21}
}
A series of 3-benzylamino-and 3-arylalkylaminocarbonyl [1, 2, 4]triazino [4, 3-a]benzimidazoles 1-12 were synthesized and biologically assayed as geometrically constrained analogues of N-benzylindolylglyoxylylamides II, which are high affinity ligands at the benzodiazepine receptor (BzR). The intermediate 3-ethoxycarbonyl [1, 2, 4]triazino [4, 3-a… CONTINUE READING