Geometric diversity through permutation of backbone configuration in cyclic peptide libraries.

@article{Perlman2005GeometricDT,
  title={Geometric diversity through permutation of backbone configuration in cyclic peptide libraries.},
  author={Zachary E. Perlman and Jonathan E Bock and Jeffrey R. Peterson and R Scott Lokey},
  journal={Bioorganic & medicinal chemistry letters},
  year={2005},
  volume={15 23},
  pages={5329-34}
}
Cyclic peptides offer the possibility of varying both scaffold geometry and R-group functionality. For example, parameters such as ring size and the placement of D-amino acid and proline residues can have a dramatic effect on the conformations of cyclic peptides, allowing access to structurally diverse species based on simple modifications in their linear… CONTINUE READING