Geometric determinants of the place fields of hippocampal neurons

@article{OKeefe1996GeometricDO,
  title={Geometric determinants of the place fields of hippocampal neurons},
  author={John O’Keefe and Neil Burgess},
  journal={Nature},
  year={1996},
  volume={381},
  pages={425-428}
}
THE human hippocampus has been implicated in memory1, in particular episodic2,3 or declarative4 memory. In rats, hippocampal lesions cause selective spatial deficits2,5–7, and hippocampal complex spike cells (place cells) exhibit spatially localized firing8,9, suggesting a role in spatial memory2, although broader functions have also been suggested10,11. Here we report the identification of the environmental features controlling the location and shape of the receptive fields (place fields) of… Expand
The global record of memory in hippocampal neuronal activity
TLDR
Training rats to perform the same recognition memory task in several distinct locations in a rich spatial environment found that the activity of many hippocampal neurons was related consistently to perceptual, behavioural or cognitive events, regardless of the location where these events occurred, indicating that non-spatial events are fundamental elements of hippocampal representation. Expand
Field repetition and local mapping in the hippocampus and the medial entorhinal cortex.
TLDR
It is argued that the repetition of firing fields can be a useful tool for understanding the relationship between grid cells in the entorhinal cortex and place cells inThe hippocampus, the spatial inputs shared by these cells, and the propagation of spatially related signals through these structures. Expand
Spatial and memory circuits in the medial entorhinal cortex
TLDR
It is proposed that separate circuits within the medial entorhinal cortex are specialized for performing either spatial or memory-related computations. Expand
Place cells, navigational accuracy, and the human hippocampus.
TLDR
The left human hippocampus retains its role in spatial mapping as demonstrated by its activation during accurate navigation in imagined and virtual reality environments and may have taken on wider memory functions, perhaps by the incorporation of a linear time tag. Expand
Space and context in the temporal cortex
TLDR
A simple mechanism, based on place field density across an environment, is described that could allow hippocampal representations to be “read” by other brain regions for the purpose of navigation. Expand
Preserved performance in a hippocampal‐dependent spatial task despite complete place cell remapping
TLDR
Although the change from black to white induced remapping of most place cells, navigational performance remained essentially intact, suggesting that the spatial information needed to solve this navigation task is represented outside the hippocampus and suggest that the place cells encode some other aspect, such as the spatial context. Expand
Models of spatial representation in the medial entorhinal cortex
High-level cognitive abilities such as memory, navigation, and decision making rely on the communication between the hippocampal formation and the neocortex. At the interface between these two brainExpand
Influence of boundary removal on the spatial representations of the medial entorhinal cortex
TLDR
Results show that manipulation of local boundaries can exert a powerful influence on the spatial firing patterns of MEC cells even when the manipulations leave global cues unchanged and allow uninterrupted, self‐motion‐based localization, and suggest the presence of landmark‐related information in MEC, which might prevent cumulative drift of the spatial representation or might reset it to a previously learned configuration in a familiar environment. Expand
Spatial Firing of Hippocampal Place Cells in Blind Rats
TLDR
This study studied place cell activity in early blind rats and found that these rats had place cells very similar to those recorded from sighted rats, suggesting that early vision is not necessary for normal firing of hippocampal place cells. Expand
Learning an Efficient Hippocampal Place Map from Entorhinal Inputs Using Non-Negative Sparse Coding
TLDR
A unified learning model is proposed that can describe the spatial tuning properties of both hippocampal place cells and dentate gyrus granule cells based on non-negative sparse coding from EC inputs and suggests that sparse coding may be one of the underlying organizing principles for the navigational system of the brain. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 25 REFERENCES
Place navigation impaired in rats with hippocampal lesions
TLDR
It is reported that, in addition to a spatial discrimination impairment, total hippocampal lesions also cause a profound and lasting placenavigational impairment that can be dissociated from correlated motor, motivational and reinforcement aspects of the procedure. Expand
Computer simulation of hippocampal place cells
TLDR
A model in which pyramidal cells are the output layer of a competitive-learning, pattern-classification device and patterns of environmental stimuli as viewed by a computerized “rat” from various locations within a simulated environment is presented. Expand
The firing of hippocampal place cells predicts the future position of freely moving rats
  • R. Muller, J. Kubie
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1989
TLDR
The results suggest that hippocampal unit activity predicts the animal's future location on a short time scale. Expand
A model of hippocampal function
TLDR
A model of hippocampal function is presented in which the firing rate maps of cells downstream of the hippocampus provide a ''population vector'' encoding the instantaneous direction of the rat from a previously encountered reward site, enabling navigation to it. Expand
Place cells, head direction cells, and the learning of landmark stability
TLDR
It appears that the strength of cue control over place cells and head direction cells depends on the rat's learned perception of the stability of the cues. Expand
The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat.
TLDR
Preliminary observations on the behaviour of hippocampusal units in the freely moving rat provide support for this theory of hippocampal function. Expand
The effects of changes in the environment on the spatial firing of hippocampal complex-spike cells
  • R. Muller, J. Kubie
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1987
TLDR
The response of place cells to changes in the animal's environment was investigated using the techniques set out in the preceding paper and the firing pattern of a cell in an apparatus of one shape could not be predicted from a knowledge of the firing patterns in the other shape. Expand
Binding of hippocampal CA1 neural activity to multiple reference frames in a landmark-based navigation task
TLDR
The results suggest that in this task a subpopulation of hippocampal cells encodes location in the fixed spatial frame, whereas other subpopulations encode location with respect to different reference frames associated with the task-relevant, mobile objects. Expand
Place units in the hippocampus of the freely moving rat
TLDR
The results suggest that place units were not responding to a simple sensory stimulus nor to a specific motor behavior, and are interpreted as strong support for the cognitive map theory of hippocampal function. Expand
The Hippocampal System and Declarative Memory in Animals
  • H. Eichenbaum
  • Psychology, Medicine
  • Journal of Cognitive Neuroscience
  • 1992
Theoretical arguments and empirical data are presented in favor of the hypothesis that the hippocampal system supports a declarative memory capacity in animals as well as humans. This view isExpand
...
1
2
3
...